Biomarker Failures

Why your new cancer biomarker may never work: recurrent patterns and remarkable diversity in biomarker failures.

Less than 1% of published cancer biomarkers actually enter clinical practice. Although best practices for biomarker development are published, optimistic investigators may not appreciate the statistical near-certainty and diverse modes by which the other 99% (likely including your favorite new marker) do indeed fail. Here, patterns of failure were abstracted for classification from publications...

Investigating transition pathways and transition failures and proposing policy solutions to cope with transition failures; Iran’s wind turbine industry

This paper aims to investigate transition paths and reasons of failure of Iran’s wind turbines industry in transition to sustainability successfully. In this regard, a qualitative approach and case study strategy have been used. For this purpose, based on type of national innovation system, the transition path and sustainability transition status of the wind turbines industry in selected countr...

Coordination Failures

"Controlled failures".

ASSESSING ADHESIVE BOND FAILURES: MIXED-MODE BOND FAILURES EXPLAINED By

The level of understanding of adhesive bond failures within the flight safety community is not as robust as it could be. Generally, most investigators are broadly aware of cohesion failure (fracture of the adhesive) and adhesion failure (a slick failure at the interface). They may also have some limited knowledge of common causes for bond failures such as bond-line voids, which is one cause of ...